Read e-book online Advances in Medicinal Chemistry: 4 PDF

By B. E. Maryanoff,A. B. Reitz

ISBN-10: 0444546499

ISBN-13: 9780444546494

ISBN-10: 0762300647

ISBN-13: 9780762300648

quantity four of Advances in Medicinal Chemistry is created from six chapters on a variety of themes in medicinal chemistry, together with molecular modeling, structure-based drug layout, natural synthesis, peptide conformational research, organic evaluation, structure-activity correlation, and lead optimization. bankruptcy 1 offers an account approximately amino acid-based peptide mimetics equivalent to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. bankruptcy 2 addresses new features of the medicinal chemistry of the $64000 anticancer drug Taxol® (paclitaxel). bankruptcy three relates an account of the quest for brand spanking new medications for the remedy of malaria in response to the traditional product artemisinin. bankruptcy four applies computational chemistry to the evaluate of compound libraries for organic checking out. bankruptcy five describes the development of a three-d molecular version of the human thrombin receptor, the 1st protease-activated G-protein coupled receptor (PAR-1), as a method to discover the intermolecular contacts enthusiastic about agonist peptide acceptance. ultimately, bankruptcy 6 describes the learn performed at Merck on inhibitors of farnesyl transferase as a possible remedy for human cancers.

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Advances in Medicinal Chemistry: 4 by B. E. Maryanoff,A. B. Reitz

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